CALL FOR PAPERS Cardiovascular-Kidney Interactions in Health and Disease D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure
نویسندگان
چکیده
Zhiwei Yang, Laureano D. Asico, Peiying Yu, Zheng Wang, John E. Jones, Crisanto S. Escano, Xiaoyan Wang, Mark T. Quinn, David R. Sibley, Guillermo G. Romero, Robin A. Felder, and Pedro A. Jose Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China; Department of Pediatrics, Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, D.C.; Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana; National Institute of Neurological Disorders and Stroke, Bethesda, Maryland; Dept. of Pharmacology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania , Department of Pathology, The University of Virginia Center for the Health Sciences, Charlottesville, Virginia
منابع مشابه
D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure.
Activation of D1-like receptors (D1 and/or D5) induces antioxidant responses; however, the mechanism(s) involved in their antioxidant actions are not known. We hypothesized that stimulation of the D5 receptor inhibits NADPH oxidase activity, and thus the production of reactive oxygen species (ROS). We investigated this issue in D5 receptor-deficient (D5-/-) and wild-type (D5+/+) mice. NADPH oxi...
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THIS ISSUE CONTAINS 11 refereed manuscripts that describe work presented at the eighth Cardiovascular-Kidney Interactions in Health and Disease Meeting at Amelia Island Plantation, FL, on May 27–30, 2005. The three-day meeting featured original contributions on a broad range of topics including redox regulation and microvascular function, genetic and cellular regulation of vascular growth and f...
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Seizure activity has been proposed to result in the generation of reactive oxygen species (ROS), which then contribute to seizure-induced neuronal damage and eventually cell death. Although the mechanisms of seizure-induced ROS generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. We aim to determine the sources of seizure-induced ROS and ...
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The D(2) dopamine receptor (D(2)R) is important in the pathogenesis of essential hypertension. We have already reported that systemic deletion of the D(2)R gene in mice results in reactive oxygen species (ROS)-dependent hypertension, suggesting that the D(2)R has antioxidant effects. However, the mechanism of this effect is unknown. DJ-1 is a protein that has antioxidant properties. D(2)R and D...
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Dear Editor, The O2-generating enzyme NADPH oxidase, plays a crucial role in host defense against microbial infection through the production of reactive oxygen species (ROS).1The multisubunit NADPH oxidase complex can be detected in vitro by the nitroblue tetrazolium test (NBT).2The NBT test is used for the diagnosis of chronic granulomatous disease.3 However, several factors, such as some cyto...
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